Welcome to SIMAP.

SIMAP is a database containing the similarity space formed by about all amino-acid sequences from public databases and completely sequenced genomes.

You may find sequences and protein entries of interest by fulltext search which uses an index of proteins IDs, accession numbers and descriptions, and the Biothesaurus.
Starting from your query sequence you may find the nearest sequences in SIMAP. By searching parts of your query in a suffix array of all SIMAP sequences (generated by VMATCH), this search runs much faster than BLAST.

News:

• 2012, Mar 29: Database error fixed
  Between Mar 18 and 29 the connection between the main SIMAP hit database and the SIMAP server was broken due to a NFS related bug in the latest CentOS upgrade. Therefore most of the hits were not reported in SIMAP results. We are sorry for this problem, which was not immediately recognized. By Mar 29 we have fixed the problem, so that SIMAP is fully operational again.
  
• 2012, Mar 18: InterPro 36.0 integrated
  InterPro annotations have been upgraded to version 36.0 in the March 2012 release of SIMAP.
• 2012, Jan 25: InterPro 35.0 integrated
  InterPro annotations have been upgraded to version 35.0 in the January 2012 release of SIMAP.
• 2011, Oct 16: InterPro 34.0 integrated
  InterPro annotations have been upgraded to version 34.0 in the October 2011 release of SIMAP.
• 2011, Sep 25: InterPro 33.0 integrated
  InterPro annotations have been upgraded to version 33.0 in the September 2011 release of SIMAP.
• 2011, May 10: Webservice moved to Vienna
  The SIMAP webservice has moved to a new server in Vienna. The WSDL file and the SimpAT package have been updated.